Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to
membrane-bound proteins, have been successfully produced in baculovirus-infected insect …

Gradients of axon guidance molecules have long been postulated to control the
development of the organization of neural connections into topographic maps. We review …

The retinotectal projection is a premier model system for the investigation of molecular
mechanisms that underlie axon pathfinding and map formation. Other important features …

A central goal of modern neuroscience is to obtain a mechanistic understanding of higher
brain functions under healthy and diseased conditions. Addressing this challenge requires …

The conditional expression of transgenes at high levels in sparse and specific populations of
neurons is important for high-resolution optogenetic analyses of neuronal circuits. We …

The optic tectum is a visual center in vertebrates. It receives topographically ordered visual
inputs from the retina in the superficial layers and then sends motor outputs from the deeper …

Visual system development is dependent on correct interpretation of cues that direct growth
cone migration and axon branching. Mutations in the zebrafish esrom gene disrupt bundling …

The zebrafish retinotectal projection provides an attractive model system for studying many
aspects of topographic map formation and maintenance. Visual connections initially start to …

Fgf signaling plays crucial roles in morphogenesis. Fgf19 is required for zebrafish forebrain
development. Here, we examined the roles of Fgf19 in the formation of the lens and retina in …

We previously reported efficient precision targeted integration of reporter DNA in zebrafish
and human cells using CRISPR/Cas9 and short regions of homology. Here, we apply this …