[HTML][HTML] Current evidence on the bioavailability of food bioactive peptides

L Amigo, B Hernández-Ledesma - Molecules, 2020 - mdpi.com
Food protein-derived bioactive peptides are recognized as valuable ingredients of functional
foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases …

[HTML][HTML] New insights into the role of seed oil body proteins in metabolism and plant development

Q Shao, X Liu, T Su, C Ma, P Wang - Frontiers in plant science, 2019 - frontiersin.org
Oil bodies (OBs) are ubiquitous dynamic organelles found in plant seeds. They have
attracted increasing attention recently because of their important roles in plant physiology …

N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex

DC Scott, JK Monda, EJ Bennett, JW Harper… - Science, 2011 - science.org
Although many eukaryotic proteins are amino (N)–terminally acetylated, structural
mechanisms by which N-terminal acetylation mediates protein interactions are largely …

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

D Xitong, Z Xiaorong - Gene, 2016 - Elsevier
Exosomes are 30–120 nm membrane bound vesicles secreted naturally by almost all cells
and exist in all body fluids. Accumulating evidence has shown that exosomes contain …

N‐terminal methionine processing

PT Wingfield - Current protocols in protein science, 2017 - Wiley Online Library
Protein synthesis is initiated by methionine in eukaryotes and by formylmethionine in
prokaryotes. N‐terminal methionine can be co‐translationally cleaved by the enzyme …

[HTML][HTML] The N-terminal methionine of cellular proteins as a degradation signal

HK Kim, RR Kim, JH Oh, H Cho, A Varshavsky… - Cell, 2014 - cell.com
The Arg/N-end rule pathway targets for degradation proteins that bear specific unacetylated
N-terminal residues while the Ac/N-end rule pathway targets proteins through their N α …

The N-end rule pathway: emerging functions and molecular principles of substrate recognition

SM Sriram, BY Kim, YT Kwon - Nature reviews Molecular cell biology, 2011 - nature.com
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

DJ Gibbs, J Bacardit, A Bachmair, MJ Holdsworth - Trends in Cell Biology, 2014 - cell.com
The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the
nature of its N-terminus, has emerged as a key regulator of diverse processes in eukaryotes …

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

SE Park, JM Kim, OH Seok, H Cho, B Wadas, SY Kim… - Science, 2015 - science.org
Rgs2, a regulator of G proteins, lowers blood pressure by decreasing signaling through Gαq.
Human patients expressing Met-Leu-Rgs2 (ML-Rgs2) or Met-Arg-Rgs2 (MR-Rgs2) are …

N‐terminal acetylation of α‐synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

L Kang, GM Moriarty, LA Woods, AE Ashcroft… - Protein …, 2012 - Wiley Online Library
The conformational properties of soluble α‐synuclein, the primary protein found in patients
with Parkinson's disease, are thought to play a key role in the structural transition to amyloid …