Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves
cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by …

The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

PF-543 is a sphingosine kinase 1 (SPHK1) inhibitor developed by Pfizer and is currently
considered the most potent selective SPHK1 inhibitor. SPHK1 catalyses the production of …

Thromboembolic complications and excessive inflammation are frequent in severe COVID-
19, potentially leading to long COVID. In non-COVID studies, we and others demonstrated …

Under normal conditions, the blood-brain barrier effectively regulates the passage of
immune cells into the central nervous system (CNS). However, under pathological …

Objective: Reelin and its receptor Apoer2 (apolipoprotein E receptor 2) play a prominent role
in endothelial cell dysfunction by promoting leukocyte–endothelial cell adhesion, an …

Pulmonary arterial hypertension (PAH) is a vasculopathy characterized by sustained
elevated pulmonary arterial pressures in which the pulmonary vasculature undergoes …

Pulmonary arterial hypertension (PAH) is a progressive condition with an unmet need for
early diagnosis, better monitoring, and risk stratification. The receptor for advanced glycation …