Use of precision cut lung slices as a translational model for the study of lung biology
G Liu, C Betts, DM Cunoosamy, PM Åberg… - Respiratory …, 2019 - Springer
Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …
data generated in genetically homogeneous animals housed in a clean and well-controlled …
Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions
P Dey - Pharmacological research, 2019 - Elsevier
The dynamic and delicate interactions amongst intestinal microbiota, metabolome and
metabolism dictates human health and disease. In recent years, our understanding of gut …
metabolism dictates human health and disease. In recent years, our understanding of gut …
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
H Li, Y Xiao, Q Li, J Yao, X Yuan, Y Zhang, X Yin… - Cancer cell, 2022 - cell.com
Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective
analyses revealed that cancer patients who took antihistamines during immunotherapy …
analyses revealed that cancer patients who took antihistamines during immunotherapy …
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation
M Bruchard, C Rebé, V Derangère, D Togbé… - Nature …, 2015 - nature.com
The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates
caspase-1 and mediates the release of interleukin 1β (IL-1β) and IL-18. Whether NLRP3 can …
caspase-1 and mediates the release of interleukin 1β (IL-1β) and IL-18. Whether NLRP3 can …
Animal models of asthma: utility and limitations
MV Aun, R Bonamichi-Santos… - Journal of asthma …, 2017 - Taylor & Francis
Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to …
Animal models have been developed to better understand these mechanisms and to …
[HTML][HTML] Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses
TYF Halim, YY Hwang, ST Scanlon, H Zaghouani… - Nature …, 2016 - nature.com
Rapid activation of memory CD4+ T helper 2 (TH2) cells during allergic inflammation
requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate …
requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate …
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …
Mouse models of allergic asthma: acute and chronic allergen challenge
AT Nials, S Uddin - Disease models & mechanisms, 2008 - journals.biologists.com
Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying
physiological and immunological processes are not fully understood. Animal models have …
physiological and immunological processes are not fully understood. Animal models have …
Phthalate exposure and asthma in children
CG Bornehag, E Nanberg - International journal of andrology, 2010 - Wiley Online Library
During the last decades more than 100 000 new chemicals have been introduced to the
environment. Many of these new chemicals and many common consumer products that …
environment. Many of these new chemicals and many common consumer products that …
[HTML][HTML] An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
RS Allan, E Zueva, F Cammas, HA Schreiber… - Nature, 2012 - nature.com
During immune responses, naive CD4+ T cells differentiate into several T helper (TH) cell
subsets under the control of lineage-specifying genes. These subsets (TH1, TH2 and TH17 …
subsets under the control of lineage-specifying genes. These subsets (TH1, TH2 and TH17 …