Use of precision cut lung slices as a translational model for the study of lung biology

G Liu, C Betts, DM Cunoosamy, PM Åberg… - Respiratory …, 2019 - Springer
Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

P Dey - Pharmacological research, 2019 - Elsevier
The dynamic and delicate interactions amongst intestinal microbiota, metabolome and
metabolism dictates human health and disease. In recent years, our understanding of gut …

The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1

H Li, Y Xiao, Q Li, J Yao, X Yuan, Y Zhang, X Yin… - Cancer cell, 2022 - cell.com
Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective
analyses revealed that cancer patients who took antihistamines during immunotherapy …

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

M Bruchard, C Rebé, V Derangère, D Togbé… - Nature …, 2015 - nature.com
The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates
caspase-1 and mediates the release of interleukin 1β (IL-1β) and IL-18. Whether NLRP3 can …

Animal models of asthma: utility and limitations

MV Aun, R Bonamichi-Santos… - Journal of asthma …, 2017 - Taylor & Francis
Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to …

[HTML][HTML] Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

TYF Halim, YY Hwang, ST Scanlon, H Zaghouani… - Nature …, 2016 - nature.com
Rapid activation of memory CD4+ T helper 2 (TH2) cells during allergic inflammation
requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate …

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

F Huang, H Zhang, M Wu, H Yang… - Proceedings of the …, 2012 - National Acad Sciences
Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …

Mouse models of allergic asthma: acute and chronic allergen challenge

AT Nials, S Uddin - Disease models & mechanisms, 2008 - journals.biologists.com
Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying
physiological and immunological processes are not fully understood. Animal models have …

Phthalate exposure and asthma in children

CG Bornehag, E Nanberg - International journal of andrology, 2010 - Wiley Online Library
During the last decades more than 100 000 new chemicals have been introduced to the
environment. Many of these new chemicals and many common consumer products that …

[HTML][HTML] An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

RS Allan, E Zueva, F Cammas, HA Schreiber… - Nature, 2012 - nature.com
During immune responses, naive CD4+ T cells differentiate into several T helper (TH) cell
subsets under the control of lineage-specifying genes. These subsets (TH1, TH2 and TH17 …