RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have
been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated …

Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …

Tissue-resident macrophages can derive from yolk sac macrophages (YS-Macs), fetal liver
monocytes (FL-MOs), or adult bone-marrow monocytes (BM-MOs). The relative capacity of …

NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to
the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and …

Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …

Nutrient sensing and damage sensing are two fundamental processes in living organisms.
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …

The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and
tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral …

ABSTRACT RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible
gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to …