Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

[HTML][HTML] Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota

W Fusco, MB Lorenzo, M Cintoni, S Porcari… - Nutrients, 2023 - mdpi.com
Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut
homeostasis and their deficiency is involved in the pathogenesis of several disorders …

The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

A Nogal, AM Valdes, C Menni - Gut microbes, 2021 - Taylor & Francis
The gut microbiota plays an important role in cardio-metabolic diseases with diet being
among the strongest modulators of gut microbiota composition and function. Resistant …

[HTML][HTML] The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome

P Markowiak-Kopeć, K Śliżewska - Nutrients, 2020 - mdpi.com
The relationship between diet and the diversity and function of the intestinal microbiome and
its importance for human health is currently the subject of many studies. The type and …

Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health

A Mukherjee, C Lordan, RP Ross, PD Cotter - Gut microbes, 2020 - Taylor & Francis
Over the last two decades our understanding of the gut microbiota and its contribution to
health and disease has been transformed. Among a new 'generation'of potentially beneficial …

[HTML][HTML] Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

CH Kim - Cellular & molecular immunology, 2021 - nature.com
A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases

R Hariharan, EN Odjidja, D Scott, N Shivappa… - Obesity …, 2022 - Wiley Online Library
An unhealthy diet is a recognized risk factor in the pathophysiology of numerous chronic
noncommunicable diseases (NCD), including obesity, type 2 diabetes (T2DM), and …

[HTML][HTML] Free fatty acid receptors in health and disease

I Kimura, A Ichimura, R Ohue-Kitano… - Physiological …, 2019 - journals.physiology.org
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

[HTML][HTML] Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases

D Parada Venegas, MK De la Fuente… - Frontiers in …, 2019 - frontiersin.org
Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel
Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial …

[HTML][HTML] Intestinal microbiota-derived short chain fatty acids in host health and disease

J Cong, P Zhou, R Zhang - Nutrients, 2022 - mdpi.com
Intestinal microbiota has its role as an important component of human physiology. It
produces metabolites that module key functions to establish a symbiotic crosstalk with their …