[HTML][HTML] Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases

MJ Kim, JH Jeon - International Journal of Molecular Sciences, 2022 - mdpi.com
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis

MJ López-Armada, JA Fernández-Rodríguez… - Antioxidants, 2022 - mdpi.com
Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

[HTML][HTML] Xinfeng capsule inhibits inflammation and oxidative stress in rheumatoid arthritis by up-regulating LINC00638 and activating Nrf2/HO-1 pathway

Y Sun, J Liu, L Xin, J Wen, Q Zhou, X Chen… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Xinfeng capsule is a traditional Chinese medicine
compound, which has been clinically used for more than 20 years in the treatment of …

Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-κB pathways

Y Chen, S Xu, Y Lu, S Chen, X Du, S Hou… - Chemico-Biological …, 2021 - Elsevier
Abstract Background Inflammatory bowel diseases (IBDs), which mainly include Crohn's
disease (CD) and ulcerative colitis (UC), are chronic idiopathic inflammatory disease of the …

[HTML][HTML] Nrf2 activation improves experimental rheumatoid arthritis

A Zhang, T Suzuki, S Adachi, E Yoshida… - Free Radical Biology …, 2023 - Elsevier
Rheumatoid arthritis is a systemic autoimmune disease with pain and functional disorder of
joints. Multiple strategies toward treatment of the rheumatoid arthritis are operating, while …

[HTML][HTML] Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

T Balendran, K Lim, JA Hamilton… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …

[HTML][HTML] Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

K Taing, L Chen, HR Weng - Neural Regeneration Research, 2023 - journals.lww.com
Neuroinflammation plays a critical role in the pathological process of multiple neurological
disorders and pathological pain conditions. GPR109A, a Gi protein-coupled receptor, has …

Evaluation of antiarthritic and antinociceptive effects of cedrol in a rat model of arthritis

F Forouzanfar, AM Pourbagher-Shahri… - … Medicine and Cellular …, 2022 - Wiley Online Library
Pharmacological studies revealed that cedrol, a natural sesquiterpene, has antioxidant, anti‐
inflammatory, and analgesic properties. This study is aimed at evaluating the potential …

[HTML][HTML] 8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome

J Cheng, X Ma, H Zhang, X Wu, M Li, G Ai… - Biomedicine & …, 2022 - Elsevier
Palmatine (PAL) is an isoquinoline alkaloid derived from Fibraureae caulis Pierre that has
been used to relieve inflammatory diseases like ulcerative colitis (UC). The metabolites of …

Nrf2 regulates CHI3L1 to suppress inflammation and improve post-traumatic osteoarthritis

Y Song, D Hao, H Jiang, M Huang, Q Du… - Journal of …, 2021 - Taylor & Francis
Introduction Post-traumatic osteoarthritis (PTOA) is an inflammatory condition that occurs
following mechanical joint trauma and that results in joint degeneration. This study sought to …