At the core of nucleotide excision repair
Nucleotide excision repair (NER) is unique in its ability to identify and remove vastly different
lesions from DNA. Recent advances in the structural characterization of complexes involved …
lesions from DNA. Recent advances in the structural characterization of complexes involved …
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …
STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
D van den Heuvel, M Rodríguez-Martínez… - Cell, 2024 - cell.com
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA
polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of …
polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of …
TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair
Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause
severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining …
severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining …
Differing structures and dynamics of two photolesions portray verification differences by the human XPD helicase
I Fu, NE Geacintov, S Broyde - Nucleic acids research, 2023 - academic.oup.com
Ultraviolet light generates cyclobutane pyrimidine dimer (CPD) and pyrimidine 6− 4
pyrimidone (6− 4PP) photoproducts that cause skin malignancies if not repaired by …
pyrimidone (6− 4PP) photoproducts that cause skin malignancies if not repaired by …
XPD stalled on cross-linked DNA provides insight into damage verification
The superfamily 2 helicase XPD is a central component of the general transcription factor II
H (TFIIH), which is essential for transcription and nucleotide excision DNA repair (NER) …
H (TFIIH), which is essential for transcription and nucleotide excision DNA repair (NER) …
The nucleotide excision repair proteins through the lens of molecular dynamics simulations
Mutations that affect the proteins responsible for the nucleotide excision repair (NER)
pathway can lead to diseases such as xeroderma pigmentosum, trichothiodystrophy …
pathway can lead to diseases such as xeroderma pigmentosum, trichothiodystrophy …
Characterization of human XPD helicase activity with single-molecule magnetic tweezers
C Mao, M Mills - Biophysical Journal, 2024 - cell.com
XPD helicase is a DNA-unwinding enzyme involved in DNA repair. As part of TFIIH, XPD
opens a repair bubble in DNA for access by proteins in the nucleotide excision repair …
opens a repair bubble in DNA for access by proteins in the nucleotide excision repair …
Variation in ultraviolet-B (UV-B)-induced DNA damage repair mechanisms in plants and humans: an avenue for developing protection against skin photoaging
GS Mmbando - International Journal of Radiation Biology, 2024 - Taylor & Francis
Purpose The increasing amounts of ultraviolet-B (UV-B) light in our surroundings have
sparked worries about the possible effects on humans and plants. The detrimental effects of …
sparked worries about the possible effects on humans and plants. The detrimental effects of …
[PDF][PDF] NAR Breakthrough Article A scanning-to-incision switch in TFIIH-XPG induced
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …