DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …

Autoantibodies specific for idiopathic inflammatory myopathy (myositis-specific
autoantibodies (MSAs)) are clinically useful biomarkers to help the diagnosis of …

New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …

Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX
genes. Recent studies have implicated histone methylation in long-term gene silencing …

Enhancer of Zeste [E (z)] is a Polycomb-group transcriptional repressor and one of the
founding members of the family of SET domain-containing proteins. Several SET-domain …

Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate
gene expression by removing acetyl groups from lysine residues in histone tails, resulting in …

The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

The power of molecular genetics has dramatically advanced our understanding of all
aspects of gibberellin (GA) signaling. Many genes encoding GA response pathway …