Genome editing in cotton: challenges and opportunities
Cotton has enormous economic potential providing high-quality protein, oil, and fibre. A
large increase in cotton output is necessary due to the world's changing climate and …
large increase in cotton output is necessary due to the world's changing climate and …
Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses
Despite antiretroviral therapy (ART), HIV-1 persists as proviruses integrated into the
genomic DNA of CD4+ T cells. The mechanisms underlying the persistence and clonal …
genomic DNA of CD4+ T cells. The mechanisms underlying the persistence and clonal …
Antigen specificities and proviral integration sites differ in HIV-infected cells by timing of antiretroviral treatment initiation
J Joy, A Gervassi, L Chen, B Kirshenbaum… - The Journal of Clinical …, 2024 - jci.org
Despite effective antiretroviral therapy (ART), persons living with HIV harbor reservoirs of
persistently infected CD4+ cells, which constitute a barrier to cure. Initiation of ART during …
persistently infected CD4+ cells, which constitute a barrier to cure. Initiation of ART during …
Activation of HIV-1 proviruses increases downstream chromatin accessibility
It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
The state-of-the-art of gene editing and its application to viral infections and diseases including COVID-19
Gene therapy delivers a promising hope to cure many diseases and defects. The discovery
of gene-editing technology fueled the world with valuable tools that have been employed in …
of gene-editing technology fueled the world with valuable tools that have been employed in …
High Diversity of Long Terminal Repeat Retrotransposons in Compact Vertebrate Genomes: Insights from Genomes of Tetraodontiformes
Simple Summary Long terminal repeat retrotransposons (LTR-RTNs) are vital in genome
evolution and diversity. The compact genomes of Tetraodontiformes provide an excellent …
evolution and diversity. The compact genomes of Tetraodontiformes provide an excellent …