Multisystem physiological perspective of human frailty and its modulation by physical activity
JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
[HTML][HTML] Frailty and sarcopenia: the potential role of an aged immune system
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …
muscle mass, quality and strength, is more common in older adults and has been …
Molecular mechanisms of biological aging in intervertebral discs
NV Vo, RA Hartman, PR Patil… - Journal of …, 2016 - Wiley Online Library
Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
Oxidative stress and vascular inflammation in aging
M El Assar, J Angulo, L Rodríguez-Mañas - Free Radical Biology and …, 2013 - Elsevier
Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …
Inflammaging as a target for healthy ageing
B Dugan, J Conway, NA Duggal - Age and Ageing, 2023 - academic.oup.com
Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …
Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA
E Kotronia, H Brown, AO Papacosta, LT Lennon… - Scientific reports, 2021 - nature.com
Preventing deterioration of oral health in older age can be crucial for survival. We aimed to
examine associations of oral health problems with all-cause, cardiovascular disease (CVD) …
examine associations of oral health problems with all-cause, cardiovascular disease (CVD) …
Dietary quality is related to frailty in community-dwelling older adults
J Bollwein, R Diekmann, MJ Kaiser… - … Series A: Biomedical …, 2013 - academic.oup.com
Background. The etiology of the geriatric syndrome frailty is multifactorial. Besides hormonal
and inflammatory processes, nutritional influences may be of major relevance. In this cross …
and inflammatory processes, nutritional influences may be of major relevance. In this cross …
A review and hypothesized model of the mechanisms that underpin the relationship between inflammation and cognition in the elderly
M Tangestani Fard, C Stough - Frontiers in aging neuroscience, 2019 - frontiersin.org
Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …
[HTML][HTML] Sleep duration and sarcopenia: an updated systematic review and meta-analysis
X Li, J He, Q Sun - Journal of the American Medical Directors Association, 2023 - Elsevier
Objectives In adults, short and long sleep duration has been associated with sarcopenia
risk. Studies have shown that various factors, including biological and psychological factors …
risk. Studies have shown that various factors, including biological and psychological factors …
A free radical theory of frailty
J Vina, C Borras, MC Gomez-Cabrera - Free Radical Biology and Medicine, 2018 - Elsevier
The free radical theory of ageing provided an intellectual framework for many laboratories
working on ageing. However, experimental and clinical evidence showing that high doses of …
working on ageing. However, experimental and clinical evidence showing that high doses of …