TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …

Mast cells are tissue-inhabiting cells that play an important role in inflammatory diseases of
the airway tract. Mast cells arise in the bone marrow as progenitor cells and complete their …

Mucus secretion and mucociliary transport are essential defense mechanisms of the
airways. Deviations in mucus composition and secretion can impede mucociliary transport …

TMEM16A is a Ca2+ activated Cl− channel with important functions in airways, intestine,
and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic …

Objectives: Luteolin is the active component of Perilla frutescens, an herb for the treatment of
allergy in Asia. In this study, we aimed to investigate the effects and mechanisms of luteolin …

TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …

The dysfunction and defects of ion channels are associated with many human diseases,
especially for loss-of-function mutations in ion channels such as cystic fibrosis …

The nervous system mediates key airway protective behaviors, including cough, mucus
secretion, and airway smooth muscle contraction. Thus, its involvement and potential …

Background Allergic inflammation affects the epithelial cell populations resulting in goblet
cell hyperplasia and decreased ciliated cells. Recent advances in single‐cell RNA …

Abstract Background Transmembrane protein 16A (TMEM16A) Ca 2+-activated Cl−
channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid …