Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …

This article presents basic principles of hydrophone measurements, including mechanisms
of action for various hydrophone designs, sensitivity and directivity calibration procedures …

Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect
the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy …

Transcranial focused ultrasound (tFUS) is a promising technique for non-invasive and
spatially targeted neuromodulation and treatment of brain diseases. Acoustic lenses were …

A Sonalleve magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)
clinical system (Profound Medical, Mississauga, ON, Canada) has been shown to generate …

One of the challenges of transcutaneous high-intensity focused ultrasound (HIFU) therapies,
especially ones relying heavily on shock formation, such as boiling histotripsy (BH), is the …

Mechanical ultrasound surgery methods use short, high-intensity pulses to fractionate
tissues. This study reports the development of a two-step technology for low-energy …

Boiling histotripsy (BH) is a mechanical tissue liquefaction method that uses sequences of
millisecond-long high intensity focused ultrasound (HIFU) pulses with shock fronts. The BH …

Extracorporeal boiling histotripsy (BH), a noninvasive method for mechanical tissue
disintegration, is getting closer to clinical applications. However, the motion of the targeted …