Contribution of semen to early embryo development: fertilization and beyond
M Vallet-Buisan, R Mecca, C Jones… - Human …, 2023 - academic.oup.com
BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …
development were exclusively maternally derived; hence, if issues regarding fertility and …
Mysteries and unsolved problems of mammalian fertilization and related topics
R Yanagimachi - Biology of reproduction, 2022 - academic.oup.com
Mammalian fertilization is a fascinating process that leads to the formation of a new
individual. Eggs and sperm are complex cells that must meet at the appropriate time and …
individual. Eggs and sperm are complex cells that must meet at the appropriate time and …
Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP
J Escoffier, HC Lee, S Yassine, R Zouari… - Human molecular …, 2016 - academic.oup.com
In mammals, sperm–oocyte fusion initiates Ca2+ oscillations leading to a series of events
called oocyte activation, which is the first stage of embryo development. Ca2+ signaling is …
called oocyte activation, which is the first stage of embryo development. Ca2+ signaling is …
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence
Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm
protein PLCζ has been proposed as the physiological agent that triggers the Ca2+ …
protein PLCζ has been proposed as the physiological agent that triggers the Ca2+ …
Oocyte activation deficiency: a role for an oocyte contribution?
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
Innate immunity and inflammation of the bovine female reproductive tract in health and disease
In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice
XZ Zhang, LL Wei, HJ Jin, XH Zhang, SR Chen - Cell reports, 2022 - cell.com
The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus;
however, our understanding of the physiological roles of PT in sperm is very limited. We …
however, our understanding of the physiological roles of PT in sperm is very limited. We …
Phospholipase c
CA Bill, CM Vines - Calcium signaling, 2020 - Springer
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen
different family members have been cloned. These family members have unique structures …
different family members have been cloned. These family members have unique structures …
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application
BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions
W Zhou, SJ Stanger, AL Anderson, IR Bernstein… - BMC biology, 2019 - Springer
Background The mammalian epididymis is responsible for the provision of a highly
specialized environment in which spermatozoa acquire functional maturity and are …
specialized environment in which spermatozoa acquire functional maturity and are …