The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Atherosclerosis, a chronic multifactorial disease, is closely related to the development of
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …

The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and
heart failure are the leading causes of morbidity and mortality worldwide. One of the major …