Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …

Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional
role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of …

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial
function and to adapt cellular metabolism to stress. Using a multiomics approach in …

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These
organelles have a high plasticity and are involved in dynamic processes such as …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

Within living cells, mitochondria are considered relevant sources of reactive oxygen species
(ROS) and are exposed to reactive nitrogen species (RNS). During the last decade …

Obesity leads to various changes in the body. Among them, the existing inflammatory
process may lead to an increase in the production of reactive oxygen species (ROS) and …