Oxidative stress is caused by an imbalance between the production of reactive oxygen
species (ROS) in cells and tissues and the ability of a biological system to detoxify them …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and
hypoxia during gestation is associated with significantly increased incidence of maternal …

Polyphenols are a group of phytochemicals with extensive biological functions and health-
promoting potential. These compounds are present in most foods of plant origin and their …

The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational
parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in …

Abstract Purpose of Review Preeclampsia complicates 5–10% of all pregnancies and is a
leading cause of maternal and perinatal mortality and morbidity. The placenta plays a pivotal …

The N6-methyladenosine (m6A) RNA modification regulates the expression of genes
associated with various biological and pathological processes, including spontaneous …

Advanced maternal age (AMA) pregnancy is associated with higher risks of adverse
perinatal outcomes, which may result from premature senescence of the placenta. α‐Klotho …

Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its
molecular causes and consequences remain largely undefined. Multiple hormones …