Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard
treatments for various thoracic malignancies; however, adverse pulmonary effects, like …

Introduction Previously, we reported the frequency of epidermal growth factor receptor
(EGFR) and KRAS mutations in nonsmall-cell lung cancer (NSCLC) patients in Latin …

Background Over one half of the patients diagnosed with advanced lung cancer experience
anorexia. In addition to its high incidence, cancer-induced anorexia promotes the …

Inflammation is a component of the tumor microenvironment and represents the 7th hallmark
of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating …

Background: Non-small-cell lung cancer (NSCLC) patients often exhibit neutrophilia, which
has been associated with poor clinical outcomes. However, the mechanisms that lead to …

Binding of programmed death-1 (PD-1) with its ligands (PD-L1/2) transmits a co-inhibitory
signal in activated T-cells that promotes T-cell exhaustion, leading to tumor immune evasion …

Background. The main reason for dose reduction of afatinib is gastrointestinal toxicity (GT).
In a phase II study, we analyzed anthropometrical, nutritional, and biochemical factors …

Objectives Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions
in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting …

Methods| This post hoc secondary analysis used data from a previously published,
prospective, phase 2 randomized clinical trial (RCT). 1 The trial (NCT03071705), along with …

Objective Sixteen percent of US population is Hispanic, mostly Mexican. Recently, two
independent American reports demonstrated a higher overall survival (OS) in Hispanic …