Exome sequencing and genome sequencing have the potential to improve clinical utility for
patients undergoing genetic investigations. However, evidence of clinical utility is limited to …

Digital health solutions, with apps, virtual care, and electronic medical records, are gaining
momentum across all medical disciplines, and their adoption has been accelerated, in part …

Importance Incidental findings on screening and diagnostic tests are common and may
prompt cascades of testing and treatment that are of uncertain value. No study to date has …

Purpose To evaluate the effectiveness of the Genomics ADvISER (www. genomicsadviser.
com) decision aid (DA) for selection of secondary findings (SF), compared with genetic …

Purpose Alternative models of genetic counseling are needed to meet the rising demand for
genomic sequencing. Digital tools have been proposed as a method to augment traditional …

Abstract The 100,000 Genomes Project is a hybrid clinical and research project in which
patients and parents are offered genome sequencing for cancer and rare and inherited …

Introduction The high demand for genetic tests and limited supply of genetics professionals
has created a need for alternative service delivery models. Digital tools are increasingly …

Guidelines recommend patients be informed of their incidental results (IR) when undergoing
genomic sequencing (GS), yet there are limited tools to support patients' decisions about …

Clinicians are encouraged to document the reasons for the use of a particular procedure or
test, whether or not it is in conformance with this statement. Clinicians also are advised to …

There is growing impetus to include measures of personal utility, the nonmedical value of
information, in addition to clinical utility in health technology assessment (HTA) of genomic …