Zinc homeostasis and neurodegenerative disorders

B Szewczyk - Frontiers in aging neuroscience, 2013 - frontiersin.org
Zinc is an essential trace element, whose importance to the function of the central nervous
system (CNS) is increasingly being appreciated. Alterations in zinc dyshomeostasis has …

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

M Warthon-Medina, VH Moran, AL Stammers… - European Journal of …, 2015 - nature.com
In developing countries, deficiencies of micronutrients are thought to have a major impact on
child development; however, a consensus on the specific relationship between dietary zinc …

Elevated cortical zinc in Alzheimer disease

D Religa, D Strozyk, RA Cherny, I Volitakis… - Neurology, 2006 - AAN Enterprises
Objective: To determine whether changes in brain biometals in Alzheimer disease (AD) and
in normal brain tissue are tandemly associated with amyloid β-peptide (Aβ) burden and …

[HTML][HTML] 一个新的矿物面扫描分析方法开发和地质学应用

汪方跃, 葛粲, 宁思远, 聂利青, 钟国雄 - 岩石学报, 2017 - html.rhhz.net
LA-ICP-MS 面扫描分析近些年来发展的新兴技术, 相对于其他面扫描仪器, 其具有样品制样流程
简单, 仪器购置和分析成本低, 分析时间短, 检测限低, 多元素表面分析(< 5μm) …

High concentration of zinc in sub-retinal pigment epithelial deposits

I Lengyel, JM Flinn, T Pető, DH Linkous, K Cano… - Experimental eye …, 2007 - Elsevier
One of the hallmarks of age-related macular degeneration (AMD), the leading cause of
blindness in the elderly in Western societies, is the accumulation of sub-retinal pigment …

Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel

JL Eichelsdoerfer, JA Evans, SA Slaugenhaupt… - Journal of Biological …, 2010 - ASBMB
Chelatable zinc is important in brain function, and its homeostasis is maintained to prevent
cytotoxic overload. However, certain pathologic events result in intracellular zinc …

Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles

DH Linkous, JM Flinn, JY Koh… - … of Histochemistry & …, 2008 - journals.sagepub.com
The ZNT3 protein decorates the presynaptic vesicles of central neurons harboring vesicular
zinc, and deletion of this protein removes staining for zinc. However, it has been unclear …

High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling

Y Yang, XP Jing, SP Zhang, RX Gu, FX Tang… - PloS one, 2013 - journals.plos.org
Zinc ions highly concentrate in hippocampus and play a key role in modulating spatial
learning and memory. At a time when dietary fortification and supplementation of zinc have …

Elemental mapping and quantitative analysis of Cu, Zn, and Fe in rat brain sections by laser ablation ICP-MS

B Jackson, S Harper, L Smith, J Flinn - Analytical and bioanalytical …, 2006 - Springer
This report details the application of laser ablation quadrupole ICP-MS for the (multi)
elemental mapping of 100-μm-thick sections of rat brain. The laser spot size used was 60 …

Utility of 5-(2′, 4′-dimethylphenylazo)-6-hydroxy-pyrimidine-2, 4-dione in PVC membrane for a novel green optical chemical sensor to detect zinc ion in …

AS Amin, S El-Bahy, HH El-Feky - Analytical Biochemistry, 2022 - Elsevier
Abstract In plasticized (2-nitro-phenyloctyl ether (o-NPOE)) and polyvinyl chloride (PVC)
membrane incorporating (N, N-diethyl-5-(octadecanoylimino)-5H-benzo [a] phenolxazine-9 …