The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …

Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …

Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …

Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with
no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

Advances in the study of brain development over the last decades, especially recent findings
regarding the evolutionary expansion of the human neocortex, and large-scale analyses of …

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …