Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer

RD Cervantes-Villagrana, I García-Jiménez… - Cellular …, 2023 - Elsevier
Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …

Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome

J Winkler, P Liu, K Phong, JH Hinrichs… - Proceedings of the …, 2022 - National Acad Sciences
Environmental chemicals such as bisphenol A (BPA) are thought to contribute to
carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence …

CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways

H Xu, J Wang, M Al‐Nusaif, H Ma, W Le - Cell Proliferation, 2024 - Wiley Online Library
In non‐small cell lung cancer (NSCLC), metastasis is the most common phenotype, and
autophagy plays a vital role in its regulation. However, there are limited data on how …

Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach

BS Negrutskii, LV Porubleva, A Malinowska… - Advances in Protein …, 2024 - Elsevier
Mammalian translation elongation factors eEF1A1 and eEF1A2 are 92% homologous
isoforms whose mutually exclusive tissue-specific expression is regulated during …

Intrinsic cell rheology drives junction maturation

K Sri-Ranjan, JL Sanchez-Alonso… - Nature …, 2022 - nature.com
A fundamental property of higher eukaryotes that underpins their evolutionary success is
stable cell-cell cohesion. Yet, how intrinsic cell rheology and stiffness contributes to junction …

Structural and functional view of polypharmacology

A Moya-García, T Adeyelu, FA Kruger, NL Dawson… - Scientific reports, 2017 - nature.com
Protein domains mediate drug-protein interactions and this principle can guide the design of
multi-target drugs ie polypharmacology. In this study, we associate multi-target drugs with …

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to …

JF Martin Carli, M Dzieciatkowska… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Human milk delivers critical nutritional and immunological support to human
infants. Milk fat globules (MFGs) and their associated membranes (MFGMs) contain the …

Cdc42 regulates junctional actin but not cell polarization in the Caenorhabditis elegans epidermis

Y Zilberman, J Abrams, DC Anderson, J Nance - Journal of Cell Biology, 2017 - rupress.org
During morphogenesis, adherens junctions (AJs) remodel to allow changes in cell shape
and position while preserving adhesion. Here, we examine the function of Rho guanosine …

Genes and regulatory mechanisms associated with experimentally-induced bovine respiratory disease identified using supervised machine learning methodology

MA Scott, AR Woolums, CE Swiderski, AD Perkins… - Scientific Reports, 2021 - nature.com
Bovine respiratory disease (BRD) is a multifactorial disease involving complex host immune
interactions shaped by pathogenic agents and environmental factors. Advancements in RNA …

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo

S Kim, N Rabhi, BC Blum, R Hekman, K Wynne… - Archives of …, 2020 - Springer
Triphenyl phosphate (TPhP) is an environmental PPARγ ligand, and growing evidence
suggests that it is a metabolic disruptor. We have shown previously that the structurally …