Guidelines on nicotine dose selection for in vivo research
Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …
and routes of administration for in vivo studies. The literature is replete with reports in which …
Drug-activation of brain reward pathways
RA Wise - Drug and alcohol dependence, 1998 - Elsevier
A wide variety of biologically important stimuli can serve as rewards and establish adaptive
behavior patterns in higher animals. Such stimuli act through brain mechanisms that evolved …
behavior patterns in higher animals. Such stimuli act through brain mechanisms that evolved …
Behavioral and neural consequences of prenatal exposure to nicotine
M Ernst, ET Moolchan, ML Robinson - Journal of the American Academy of …, 2001 - Elsevier
OBJECTIVE: To review evidence for the neurodevelopmental effects of in utero exposure to
nicotine. Concerns about long-term cognitive and behavioral effects of prenatal exposure to …
nicotine. Concerns about long-term cognitive and behavioral effects of prenatal exposure to …
Nicotinic acetylcholine involvement in cognitive function in animals
ED Levin, BB Simon - Psychopharmacology, 1998 - Springer
Nicotinic cholinergic systems are involved with several important aspects of cognitive
function including attention, learning and memory. Nicotinic cholinergic receptors are …
function including attention, learning and memory. Nicotinic cholinergic receptors are …
Evidence that Tobacco Smoking Increases the Density of (−)‐[3H]Nicotine Binding Sites in Human Brain
MEM Benwell, DJK Balfour… - Journal of …, 1988 - Wiley Online Library
In a postmortem study of nicotinic receptors in human brain, cigarette smoking was found to
be associated with increased (−)‐[3H] nicotine binding to membranes prepared from gyrus …
be associated with increased (−)‐[3H] nicotine binding to membranes prepared from gyrus …
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function
ML Sinkus, S Graw, R Freedman, RG Ross… - …, 2015 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …
Neuronal nicotinic acetylcholine receptors as targets for drug discovery
MW Holladay, MJ Dart, JK Lynch - Journal of medicinal chemistry, 1997 - ACS Publications
Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors
AW Bannon, MW Decker, MW Holladay, P Curzon… - Science, 1998 - science.org
Development of analgesic agents for the treatment of severe pain requires the identification
of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant= 37 …
of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant= 37 …
Genomic organization and partial duplication of the human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
J Gault, M Robinson, R Berger, C Drebing, J Logel… - Genomics, 1998 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (HGMW-approved symbol
CHRNA7) has been characterized from genomic clones. The gene is similar in structure to …
CHRNA7) has been characterized from genomic clones. The gene is similar in structure to …