Ovarian cancer therapy has remained fundamentally unchanged for 50 years, with surgery
and chemotherapy still the frontline treatments. Typically asymptomatic until advanced …

High‐grade serous carcinoma (HGSC) is the most common and malignant histological type
of epithelial ovarian cancer, the origin of which remains controversial. Currently, the …

Background Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five
major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous …

Abstract Background Pancreatic neuroendocrine neoplasms (PanNENs) fall into two
subclasses: the well-differentiated, low-to high-grade pancreatic neuroendocrine tumors …

Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the
BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination …

Epithelial ovarian cancer is the most lethal gynecologic malignancy and one of the most
common causes of cancer mortality among women worldwide. Ubiquitin-Specific Peptidase …

Simple Summary Tumor classification based on genomic features may be able to identify
new clinically relevant subtypes and disease characteristics. By integrating multiple levels of …

Acquired resistance to platinum-derived cytostatics poses major challenges in ovarian
carcinoma therapy. In this work, we show a shift in the epithelial-mesenchymal transition …

Diseases of the female reproductive system, especially malignant tumors, pose a serious
threat to women's health worldwide. One of the key factors limiting research progress in this …

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and lethal subtype of
ovarian cancer. While most patients initially respond to standard-of-care treatment, the …