Networking brainstem and basal ganglia circuits for movement

S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …

Brainstem circuits for locomotion

R Leiras, JM Cregg, O Kiehn - Annual review of neuroscience, 2022 - annualreviews.org
Locomotion is a universal motor behavior that is expressed as the output of many integrated
brain functions. Locomotion is organized at several levels of the nervous system, with …

The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish

M Carbo-Tano, M Lapoix, X Jia, O Thouvenin… - Nature …, 2023 - nature.com
The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers
graded forward locomotion. How MLR neurons recruit downstream vsx2+(V2a) …

Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

C Wyart, M Carbo-Tano, Y Cantaut-Belarif… - Nature Reviews …, 2023 - nature.com
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …

Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

JM Cregg, SK Sidhu, R Leiras, O Kiehn - Nature Neuroscience, 2024 - nature.com
The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …

Neural circuit mechanisms underlying context-specific halting in Drosophila

N Sapkal, N Mancini, DS Kumar, N Spiller, K Murakami… - Nature, 2024 - nature.com
Walking is a complex motor programme involving coordinated and distributed activity across
the brain and the spinal cord. Halting appropriately at the correct time is a critical component …

Locomotor pattern generation and descending control: a historical perspective

R Dubuc, JM Cabelguen… - Journal of …, 2023 - journals.physiology.org
The ability to generate and control locomotor movements depends on complex interactions
between many areas of the nervous system, the musculoskeletal system, and the …

Hindbrain modules differentially transform activity of single collicular neurons to coordinate movements

SH Zahler, DE Taylor, BS Wright, JY Wong… - Cell, 2023 - cell.com
Seemingly simple behaviors such as swatting a mosquito or glancing at a signpost involve
the precise coordination of multiple body parts. Neural control of coordinated movements is …

Freely behaving mice can brake and turn during optogenetic stimulation of the mesencephalic locomotor region

CI Van der Zouwen, J Boutin, M Fougère… - Frontiers in neural …, 2021 - frontiersin.org
A key function of the mesencephalic locomotor region (MLR) is to control the speed of
forward symmetrical locomotor movements. However, the ability of freely moving mammals …

Spinal cords: Symphonies of interneurons across species

AC Wilson, LB Sweeney - Frontiers in Neural Circuits, 2023 - frontiersin.org
Vertebrate movement is orchestrated by spinal inter-and motor neurons that, together with
sensory and cognitive input, produce dynamic motor behaviors. These behaviors vary from …