Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Endothelial cells are important constituents of blood vessels that play critical roles in
cardiovascular homeostasis by regulating blood fluidity and fibrinolysis, vascular tone …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Natural antioxidants represented by quercetin have been documented to be effective
against atherosclerosis. However, the related mechanisms remain largely unclear. In this …