The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Large tumours contain regions with very low intracellular O2 concentrations. Known as
hypoxia, this feature of tumours yields a highly reducing environment owing to the presence …

Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are
resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of …

Tumor resistance to ionizing irradiation and cancer cell's metastasis stimulated by radiation
often lead to anti-cancer failure, and can be negatively caused by a key role–cellular …

We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging
of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two …

Ongoing research on malignant and normal cell biology has substantially enhanced the
understanding of the biology of cancer and carcinogenesis. This has led to the development …

The fluorescence probe has attracted much attention in the detection of hypoxia-related
pathological conditions with unique advantage. However, in vivo imaging the early stages of …

Hypoxia is one of the critical features in solid tumors, and hypoxia-targeting contrast agents
(CAs) could greatly enhance the magnetic resonance imaging (MRI) of tumors by increasing …

The success of any given cancer immunotherapy relies on several key factors. In particular,
success hinges on the ability to stimulate the immune system in a controlled and precise …

Sex hormones play a pivotal role in modulating various physiological processes, with
emerging evidence underscoring their influence on cancer progression and treatment …