The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

Laboratory Animal Anaesthesia, Fourth Edition provides a basic guide to anaesthesia for a
very diverse audience needing content, with straight-forward, structured style of writing …

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the
pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Estrogens are a family of female sexual hormones with an exceptionally wide spectrum of
effects. When rats and mice are used in estrogen research they are commonly …

Rodent models constitute a cornerstone in the elucidation of the effects and biological
mechanisms of 17β-estradiol. However, a thorough assessment of the methods for long-term …

Sustained-release formulations of analgesic drugs are promising alternatives to repeated
drug injections. Here, we compared a sustained-release formulation of buprenorphine (SB …

Pain has a profound effect on an animal's wellbeing. In Germany, researchers using animals
have been legally required to reduce any possible pain, suffering, distress or lasting harm to …

Buprenorphine and carprofen, 2 of the most commonly used analgesics in mice, must be
administered every 8 to 12 h to provide sustained analgesia. Sustained-release (SR) …

Effective management of postoperative pain is an essential component of the care and
welfare of laboratory animals. A sustained-release formulation of buprenorphine (Bup-SR) …