Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …

Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

Compounds bearing thiazole and chalcone groups have been reported to be excellent
leads for antibacterial, antitubercular and anticancer activities. In view of this, we performed …

Despite the greatest achievement in the development of anti-inflammatory agents in the last
two decades, the current clinical drugs suffer from a variety of complications in community …

This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) of
thiophene carbaldehyde. All the synthesized compounds were successfully synthesized …

A series of previously synthesized 5-benzyliden-2-(5-methylthiazole-2-ylimino) thiazoli-din-4-
one were evaluated for their anti-inflammatory activity on the basis of PASS predictive …

In this paper, we describe the synthesis of a novel (E)-5-(1-(2-(4-(2, 4-dichlorophenyl) thiazol-
2-yl) hydrazineylidene) ethyl)-2, 4-dimethylthiazole (DCPTHT) via multicomponent reaction …

Without using any solvents, a green and highly efficient protocol for the preparation of
ferrocenyl chalcones has been achieved by grinding between acetylferrocene and …

The synthesis of derivatives of three nonspecific COX-1 and COX-2 inhibitors, ibuprofen,
ketoprofen, naproxen is presented. These acids were connected via an amide bond with an …

Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs (NSAID) are their
gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 …