Selenoproteins: molecular pathways and physiological roles

VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

ME Cleasby, P Jamieson, PJ Atherton - Journal of Endocrinology, 2016 - research.ed.ac.uk
Insulin resistance (IR) in skeletal muscle is a key defect mediating the link between obesity
and type 2 33 diabetes, a disease that typically affects people in later life. Sarcopenia (age …

Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse

V Agarwal, ZD Miles, JM Winter, AS Eustáquio… - Chemical …, 2017 - ACS Publications
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Thyroid function in critically ill patients

E Fliers, AC Bianco, L Langouche… - The lancet Diabetes & …, 2015 - thelancet.com
Patients in the intensive care unit (ICU) typically present with decreased concentrations of
plasma tri-iodothyronine, low thyroxine, and normal range or slightly decreased …

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

ND Solovyev - Journal of inorganic biochemistry, 2015 - Elsevier
Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

Os PT 2, a phosphate transporter, is involved in the active uptake of selenite in rice

L Zhang, B Hu, W Li, R Che, K Deng, H Li, F Yu… - New …, 2014 - Wiley Online Library
Selenite is a predominant form of selenium (Se) available to plants, especially in anaerobic
soils, but the molecular mechanism of selenite uptake by plants is not well understood. ltn1 …

How selenium has altered our understanding of the genetic code

DL Hatfield, VN Gladyshev - Molecular and cellular biology, 2002 - Am Soc Microbiol
Selenium is an essential micronutrient in the diet of many life forms, including humans and
other mammals. Significant health benefits have been attributed to this element. It is rapidly …

[HTML][HTML] Roles of selenoproteins in brain function and the potential mechanism of selenium in Alzheimer's disease

ZH Zhang, GL Song - Frontiers in Neuroscience, 2021 - frontiersin.org
Selenium (Se) and its compounds have been reported to have great potential in the
prevention and treatment of Alzheimer's disease (AD). However, little is known about the …

Selenium, the thyroid, and the endocrine system

J Kohrle, F Jakob, B Contempré… - Endocrine reviews, 2005 - academic.oup.com
Recent identification of new selenocysteine-containing proteins has revealed relationships
between the two trace elements selenium (Se) and iodine and the hormone network …

[HTML][HTML] An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status

CS Broome, F McArdle, JAM Kyle, F Andrews… - The American journal of …, 2004 - Elsevier
Background Dietary selenium intakes in many countries, including the United Kingdom, are
lower than international recommendations. No functional consequences of these lower …