Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

Objective. This study evaluated subcutaneous injections of tetrodotoxin (TTX) for the
treatment of moderate to severe, inadequately controlled cancer‐related pain. Methods …

The pharmacological treatment of cancer-related pain is unsatisfactory. Tetrodotoxin (TTX)
has shown analgesia in preclinical models and clinical trials, but its clinical efficacy and …

Purpose. Pain is among the most frequent and troubling symptoms in cancer patients.
Despite the availability of updated treatment guidelines and effective pharmacological …

The aim of this review is to summarize the current knowledge of low-dose methadone
treatment in palliative cancer care. In Sweden, methadone is quite common in specialized …

Although persistent pain in cancer patients surviving after primary treatment has been
recognized for decades, only recently has research shown how this arises and some …

Abstract Purpose of Review Pain is a prevalent symptom in the lives of patients with cancer.
In light of the ongoing opioid epidemic and increasing awareness of the potential for opioid …

Background: Opioid prescribing in the context of orthopaedic surgery has been recognized
as having a critical role in the ongoing opioid epidemic. Given the negative consequences of …

Abstract Purpose of Review In this article, we will discuss the current understanding of bone
pain and muscle weakness in cancer patients. We will describe the underlying physiology …