Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

WOUND HEALING: AN OVERVIEW OF ACUTE, FIBROTIC AND DELAYED HEALING Page 1
[Frontiers in Bioscience 9, 283-289, January 1, 2004 WOUND HEALING: AN OVERVIEW OF …

The cause of fibrotic diseases, pathologies characterized by excessive production,
deposition, and contraction of extracellular matrix, is unknown. To understand the molecular …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

Significance: Wound healing is an intricate biological process in which the skin, or any other
tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of …

Transforming growth factor-β (TGF-β), a prototype of multifunctional cytokine, is a key
regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-β …

Introduction Smad‐3, a key cytoplasmic mediator of transforming growth factor‐β (TGF‐β)
signalling, mediates many of its inflammatory and fibrotic effects in vivo (Roberts et al. 2001) …

Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including
both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms …