Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Heterochromatin affects genome function at many levels. It enables heritable gene
repression, maintains chromosome integrity and provides mechanical rigidity to the …

In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …

Biological molecules are often highly dynamic, and this flexibility can be critical for function.
The large range of sampled timescales and the fact that many of the conformers that are …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful high-resolution tool for
characterizing biomacromolecular structure, dynamics, and interactions. However, the …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and
kinetic information on biomolecular interactions, which can be extracted through the …

Progress in NMR in general and in biomolecular applications in particular is driven by
increasing magnetic-field strengths leading to improved resolution and sensitivity of the …