▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Subtraction hybridization identified melanoma differentiation-associated gene-7 (mda-7) as
a gene induced during terminal differentiation in human melanoma cells. On the basis of …

Melanoma differentiation associated gene-5 (mda-5) was identified by subtraction
hybridization as a novel upregulated gene in HO-1 human melanoma cells induced to …

Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is an active constituent of Rheum
palmatum, and showed inhibitory activity on lipopolysaccharide-induced NO production in …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

Malignant gliomas are extremely aggressive cancers currently lacking effective treatment
modalities. Gene therapy represents a promising approach for this disease. A requisite …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

An obstacle to effective gene-based cancer therapies is the limited number of cancer-
specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction …