Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis

D McGonagle, TG Baboolal, E Jones - Nature Reviews Rheumatology, 2017 - nature.com
The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells

A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

Do nonsteroidal anti‐inflammatory drugs affect bone healing? A critical analysis

I Pountos, T Georgouli, GM Calori… - The Scientific World …, 2012 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) play an essential part in our approach to
control pain in the posttraumatic setting. Over the last decades, several studies suggested …

Wharton's jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance

I Kalaszczynska, K Ferdyn - BioMed research international, 2015 - Wiley Online Library
Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to
collect lifesaving Wharton's jelly derived mesenchymal stem cells (WJ‐MSC). Evidences that …

NSAID therapy effects on healing of bone, tendon, and the enthesis

B Su, JP O'Connor - Journal of applied physiology, 2013 - journals.physiology.org
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of
skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established …

[HTML][HTML] Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review

K Nakata, T Hanai, Y Take, T Osada, T Tsuchiya… - Osteoarthritis and …, 2018 - Elsevier
Osteoarthritis (OA) is a potentially disabling disease whose progression is dependent on
several risk factors. OA management usually involves the use of non-steroidal anti …

Nonsteroidal anti-inflammatory drugs: prostaglandins, indications, and side effects

I Pountos, T Georgouli, H Bird… - International Journal of …, 2011 - Taylor & Francis
For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been part of our clinical
practice. They started out as drugs with anti-inflammatory and analgesic action, and …

The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and …

I Pountos, T Georgouli, K Henshaw, H Bird… - … of orthopaedic trauma, 2010 - journals.lww.com
Materials and Methods: Trabecular bone was obtained from 10 patients (four males, mean
age 76 years) with lower extremity osteoporotic fractures. MSCs were isolated by enzymatic …

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

KA Glass, JM Link, JM Brunger, FT Moutos… - Biomaterials, 2014 - Elsevier
The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including
interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human …

Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation

X Hu, Z Sun, F Li, C Jiang, W Yan, Y Sun - Cellular & Molecular Biology …, 2021 - Springer
Burn injury is one of the potential causes of heterotopic ossification (HO), which is a rare but
debilitating condition. The incidence ranges from 3.5 to 5.6 depending on body area. Burns …