Several decades ago, Otto Warburg discovered that cancer cells produce energy
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …

Inherited susceptibility to kidney cancer is a fascinating and complex topic. Our knowledge
about types of genetic syndromes associated with an increased risk of disease is continually …

Epigenetic modifications play a key role in the patho-physiology of many tumors and the
current use of agents targeting epigenetic changes has become a topic of intense interest in …

Hypoxia-inducible factor HIF-1 is responsible for radiation resistance and poor prognosis in
cancer therapy. As part of our drug discovery program, a novel HIF inhibitor, LW6, was …

In the last three decades huge efforts have been made to characterize genetic defects
responsible for cancer development and progression, leading to the comprehensive …

ABCG2 is a ubiquitous ATP-binding cassette transmembrane protein that is important in
clinical drug resistance. Little is known about the mechanism (s) regulating the expression of …

Background Despite therapeutic advances in targeted therapy, metastatic renal cell
carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in …

Urological cancers are a heterogeneous group of malignancies accounting for a
considerable proportion of cancer-related morbidity and mortality worldwide. Aberrant …

Background: In carcinogenesis, methylation of DNA promoter regions results in inactivation
of tumor-suppressing genes. MG98 was designed to inhibit DNA methyltransferases enzyme …

BACKGROUND: Reversibility of aberrant methylation via pharmacological means is an
attractive target for therapies through epigenetic reprogramming. To establish that …