In a biological sense, polarity refers to the extremity of the main axis of an organelle, cell, or
organism. In neurons, morphological polarity begins with the appearance of the first neurite …

Neurons develop dendritic morphologies that bear cell type-specific features in dendritic
field size and geometry, branch placement and density, and the types and distributions of …

Mislocalization and aggregation of Aβ and Tau combined with loss of synapses and
microtubules (MTs) are hallmarks of Alzheimer disease. We exposed mature primary …

Dendritic arborization patterns are consistent anatomical correlates of genetic disorders
such as Down syndrome (DS) and autism spectrum disorders (ASDs). In a screen for …

Golgi complexes (Golgi) play important roles in the development and function of neurons [1–
3]. Not only are Golgi present in the neuronal soma (somal Golgi), they also exist in the …

Background Neurons are one of the most structurally and functionally diverse cell types
found in nature, owing in large part to their unique class specific dendritic architectures …

Expression of the Down syndrome cell-adhesion molecule (Dscam) is increased in the
brains of patients with several neurological disorders. Although Dscam is critically involved …

Dendrite shape is considered a defining component of neuronal function. Yet, the
mechanisms specifying diverse dendritic morphologies, and the extent to which their …

The peripheral nervous system (PNS) of embryonic and larval stage Drosophila consists of
diverse types of sensory neurons positioned along the body wall. Sensory neurons, and …

The architectures of dendritic trees are crucial for the wiring and function of neuronal circuits
because they determine coverage of receptive territories, as well as the nature and strength …