Roles of F-box proteins in cancer
F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
Protein breakdown in cancer cachexia
M Sandri - Seminars in cell & developmental biology, 2016 - Elsevier
Skeletal muscle is a highly adaptive tissue, capable of altering muscle fiber size, functional
capacity and metabolism in response to physiological stimuli. However, pathological …
capacity and metabolism in response to physiological stimuli. However, pathological …
Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
BACKGROUND & AIMS: Deregulation of forkhead box (Fox) proteins, an evolutionarily
conserved family of transcriptional regulators, leads to tumorigenesis. Little is known about …
conserved family of transcriptional regulators, leads to tumorigenesis. Little is known about …
Epigenetic biomarkers in the management of ovarian cancer: current prospectives
Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …
[HTML][HTML] Emerging roles of F-box proteins in cancer drug resistance
L Yan, M Lin, S Pan, YG Assaraf, Z Wang… - Drug Resistance Updates, 2020 - Elsevier
Chemotherapy continues to be a major treatment strategy for various human malignancies.
However, the frequent emergence of chemoresistance compromises chemotherapy efficacy …
However, the frequent emergence of chemoresistance compromises chemotherapy efficacy …
Identification of new ovulation-related genes in humans by comparing the transcriptome of granulosa cells before and after ovulation triggering in the same controlled …
ML Wissing, SG Kristensen, CY Andersen… - Human …, 2014 - academic.oup.com
STUDY QUESTION Which genes and molecular mechanisms are involved in the human
ovulatory cascade and final oocyte maturation? SUMMARY ANSWER Up-regulated genes …
ovulatory cascade and final oocyte maturation? SUMMARY ANSWER Up-regulated genes …
Recent advances in SCF ubiquitin ligase complex: Clinical implications
N Zheng, Q Zhou, Z Wang, W Wei - … et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein)
E3 ligase complexes, play critical roles in the development and progression of human …
E3 ligase complexes, play critical roles in the development and progression of human …
SiRNA and epigenetic aberrations in ovarian cancer
Ovarian cancer has the most noteworthy lethal rate around gynecologic malignancies, and it
is also considered as the fourth most frequent cancer in the woman in world. Two most …
is also considered as the fourth most frequent cancer in the woman in world. Two most …
Targeting the MYC ubiquitination-proteasome degradation pathway for cancer therapy
Deregulated MYC overexpression and activation contributes to tumor growth and
progression. Given the short half-life and unstable nature of the MYC protein, it is not …
progression. Given the short half-life and unstable nature of the MYC protein, it is not …
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients
Background The dysregulation of transforming growth factor-β (TGF-β) signaling plays a
crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties …
crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties …