Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …

Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<
6 mm) and clinical intervention is needed for critical-size defects and beyond that along with …

Stem cell encapsulation in hydrogels has been widely employed in tissue engineering,
regenerative medicine, organ-on-a-chip devices and gene delivery; however, fabrication of …

Skeletal fragility often accompanies diabetes and does not appear to correlate with low bone
mass or trauma severity in individuals with diabetes. Instead (and in contrast to those with …

Recent innovations in bone tissue engineering have introduced biomaterials that generate
oxygen to substitute vasculature. This strategy provides the immediate oxygen required for …

Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals
with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors …

Bone remodelling is a dynamic process required for the maintenance of bone architecture in
response to the changing mechanical needs. It is also a vital process during the repair of …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …