Advanced 3D models of human brain tissue using neural cell lines: state-of-the-art and future prospects
Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to
boost our understanding of the cellular mechanisms underlying brain pathophysiology …
boost our understanding of the cellular mechanisms underlying brain pathophysiology …
In vitro neurotoxicity testing: lessons from chemotherapy-induced peripheral neurotoxicity
O Tarasiuk, C Invernizzi, P Alberti - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Chemotherapy induced peripheral neurotoxicity (CIPN) is a long-lasting, or
even permanent, late toxicity caused by largely used anticancer drugs. CIPN affects a …
even permanent, late toxicity caused by largely used anticancer drugs. CIPN affects a …
TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation
TIMAP (TGF-β-inhibited membrane associated protein) is abundant in endothelial cells, and
it has been regarded as a member of the myosin phosphatase targeting protein (MYPT) …
it has been regarded as a member of the myosin phosphatase targeting protein (MYPT) …
Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of …
GLS Sousa, NF Nadur, LAP Ferreira… - European Journal of …, 2025 - Elsevier
Inhibition of cholinesterases, combined with antioxidant activity, metal-chelating capacity,
and neuroprotection, is recognized as an effective multitarget therapy for the treatment of …
and neuroprotection, is recognized as an effective multitarget therapy for the treatment of …
[HTML][HTML] Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors
GLS Sousa, T da Silva Honório, P de Souza Furtado… - Results in …, 2024 - Elsevier
Thiosemicarbazone-acridine hybrids are prominent inhibitors of topoisomerases II. This
study reports the design, synthesis, and antiproliferative evaluation of eighteen new acridine …
study reports the design, synthesis, and antiproliferative evaluation of eighteen new acridine …
[HTML][HTML] Lipid levels correlate with neuronal and dopaminergic markers during the differentiation of SH-SY5Y cells
Parkinson's Disease (PD) is characterised by the loss of dopaminergic neurons and the
deposition of protein inclusions called Lewy Bodies (LBs). LBs are heterogeneous structures …
deposition of protein inclusions called Lewy Bodies (LBs). LBs are heterogeneous structures …
Differentiated and mature neurons are more responsive to neurotoxicant exposure at both transcriptional and translational levels
Abstract SH-SY5Y human neuroblastoma cells have been extensively used as an in vitro
model system in a diverse range of studies involving neurodevelopment, neurotoxicity …
model system in a diverse range of studies involving neurodevelopment, neurotoxicity …
Counteractions of a Novel Hydroalcoholic Extract from Lens Culinaria against the Dexamethasone-Induced Osteoblast Loss of Native Murine Cells
M Antonacci, JR Dibenedetto, F Maqoud… - Cells, 2022 - mdpi.com
The cytoprotective effects of a novel hydroalcoholic extract (0.01–5 mg/mL) from Lens
culinaria (Terre di Altamura Srl) were investigated within murine native skeletal muscle …
culinaria (Terre di Altamura Srl) were investigated within murine native skeletal muscle …
Advancing Targeted Metabolomics Using Cyanopropyl-Based Liquid Chromatography Tandem Mass Spectrometry
WR Liao, JT Lin, PC Lin, CC Chen, CF Huang… - Analytical …, 2024 - ACS Publications
The change of metabolic pathways is recognized as the key to disease discovery prompting
the development of ultra high performance liquid chromatography-tandem mass …
the development of ultra high performance liquid chromatography-tandem mass …
Distinct In Vitro Differentiation Protocols Differentially Affect Cytotoxicity Induced by Heavy Metals in Human Neuroblastoma SH-SY5Y Cells
J Ferdous, K Naitou, M Shiraishi - Biological Trace Element Research, 2024 - Springer
Abstract The SH-SY5Y cell line is widely used in neurotoxicity studies. However, the effects
of inducing cell differentiation on the cytotoxic effects of heavy metals are unclear. Therefore …
of inducing cell differentiation on the cytotoxic effects of heavy metals are unclear. Therefore …