Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

An overview of biofilm formation–combating strategies and mechanisms of action of antibiofilm agents

ST Asma, K Imre, A Morar, V Herman, U Acaroz… - Life, 2022 - mdpi.com
Biofilm formation on surfaces via microbial colonization causes infections and has become a
major health issue globally. The biofilm lifestyle provides resistance to environmental …

[HTML][HTML] Alternatives to overcoming bacterial resistances: State-of-the-art

AC Rios, CG Moutinho, FC Pinto, FS Del Fiol… - Microbiological …, 2016 - Elsevier
Worldwide, bacterial resistance to chemical antibiotics has reached such a high level that
endangers public health. Presently, the adoption of alternative strategies that promote the …

Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies

H Haddad Kashani, M Schmelcher… - Clinical microbiology …, 2018 - Am Soc Microbiol
Staphylococcus aureus is one of the most common pathogens of humans and animals,
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …

Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

Antimicrobial bacteriophage-derived proteins and therapeutic applications

DR Roach, DM Donovan - Bacteriophage, 2015 - Taylor & Francis
Antibiotics have the remarkable power to control bacterial infections. Unfortunately,
widespread use, whether regarded as prudent or not, has favored the emergence and …

Bacteriophages and phage-derived proteins–application approaches

Z Drulis-Kawa, G Majkowska-Skrobek… - Current medicinal …, 2015 - ingentaconnect.com
Currently, the bacterial resistance, especially to most commonly used antibiotics has proved
to be a severe therapeutic problem. Nosocomial and community-acquired infections are …

Development of phage lysins as novel therapeutics: a historical perspective

VA Fischetti - Viruses, 2018 - mdpi.com
Bacteriophage lysins and related bacteriolytic enzymes are now considered among the top
antibiotic alternatives for solving the mounting resistance problem. Over the past 17 years …

Gram-negative bacterial lysins

C Ghose, CW Euler - Antibiotics, 2020 - mdpi.com
Antibiotics have had a profound impact on human society by enabling the eradication of
otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid …