Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …

AMPK (5'-adenosine monophosphate-activated protein kinase) is heavily involved in
skeletal muscle metabolic control through its regulation of many downstream targets …

Idiopathic inflammatory myopathies cause progressive muscle weakness and degeneration.
Since high-dose glucocorticoids might not lead to full recovery of muscle function, physical …

Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor
signaling. This has been implicated in the development of insulin resistance. Insulin …

Key points Maternal high‐fat diet impairs brown adipocyte function and correlates with
obesity in offspring. Maternal resveratrol administration recovers metabolic activity of …

Skeletal muscle is one of the largest organs in the body and the largest protein repository.
Mitochondria are the main energy-producing organelles in cells and play an important role …

The plasminogen system is a critical proteolytic system responsible for the remodeling of the
extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen …

Glucose is a major energy source consumed by proliferating mammalian cells. Therefore, in
general, proliferating cells have the preference of high glucose contents in extracellular …

Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are
crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self …