Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in
Amoebozoa and fungi. Humans express five perilipins, which share a similar domain …

Natural ageing of organisms and corresponding age-related diseases result mainly from
stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high …

Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …

Abstract Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption.
Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …

Embryonic diapause is an enigmatic state of dormancy that interrupts the normally tight
connection between developmental stages and time. This reproductive strategy and state of …

Low-dose radiotherapy (LDR) has shown significant implications for inflaming the
immunosuppressive tumor microenvironment (TME). Surprisingly, we identify that FABP …

Liver regeneration is a dynamic and regulated process that involves inflammation,
granulation, and tissue remodeling. Hepatic macrophages, abundantly distributed in the …

Background Abundantly expressed factors in the oocyte cytoplasm can remarkably
reprogram terminally differentiated germ cells or somatic cells into totipotent state within a …

Lipid droplets (LDs) feature a unique monolayer lipid membrane that has not been
extensively studied due to the lack of suitable molecular probes that are able to distinguish …