The review demonstrates that control of posture and locomotion is provided by systems
across the caudal-to-rostral extent of the neuraxis. A common feature of the neuroanatomic …

All movements are generated by the activation of motoneurons, and hence their input-output
properties define the final step in processing of all motor commands. A major challenge to …

Serotonergic neuromodulation contributes to enhanced voluntary muscle activation.
However, it is not known how the likely motoneurone receptor candidate (5‐HT2) influences …

Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of
motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by …

Objective. All motor commands flow through motoneurons, which entrain control of their
innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action …

This study tested whether estimates of persistent inward currents (PICs) in the human
plantar flexors would increase with the level of voluntary drive. High-density surface …

Objective. Noninvasive estimation of motoneuron excitability in human motoneurons is
achieved through a paired motor unit analysis (ΔF) that quantifies hysteresis in the …

Humans with cervical spinal cord injury (SCI) often recover voluntary control of elbow flexors
and, to a much lesser extent, elbow extensor muscles. The neural mechanisms underlying …

Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be
easily recorded in human subjects. This is because of the one-to-one relationship between …

Prolonged (≥ 60 s) passive muscle stretching acutely reduces maximal force production at
least partly through a suppression of efferent neural drive. The origin of this neural …