Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …

Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …

Tuberculosis (TB) elimination is possible with the discovery of accurate biomarkers that
define the stages of infection. Drug-resistant TB impair the current treatment strategies and …

Tuberculosis (TB) has remained an unsolved problem and a major public health issue,
particularly in developing countries. Pakistan is one of the countries with the highest …

Abstract Background Type 1, type 17, and other proinflammatory cytokines are important in
host immunity to tuberculosis (TB) in animal models. However, their role in human immunity …

Impaired lung function is common in people with a history of tuberculosis. Host-directed
therapy added to tuberculosis treatment may reduce lung damage and result in improved …

Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …