The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

The pituitary gland is an important component of the endocrine system, and together with the
hypothalamus, exerts considerable influence over the functions of other endocrine glands …

The activins are pleiotropic members of the TGFβ superfamily. Within the anterior pituitary
gland, activins stimulate FSH synthesis in an autocrine/paracrine fashion by stimulating …

The mammalian anterior pituitary gland is a compound endocrine organ that regulates
reproductive development and fitness, growth, metabolic homeostasis, the response to …

FSH is critical for normal reproductive function in both males and females. Activin, a member
of the TGFβ family of growth factors, is an important regulator of FSH expression, but little is …

FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones,
including androgens, progestins, and glucocorticoids, have all been shown to stimulate …

FSH is a critical hormone regulator of gonadal function that is secreted from the pituitary
gonadotrope cell. Human patients and animal models with mutations in the LHX3 LIM …

Increased glucocorticoid secretion is a common response to stress and has been implicated
as a mediator of reproductive suppression upon the pituitary gland. We utilized …

The GnRH receptor influences gene expression in the gonadotrope through activating
signaling cascades that modulate transcription factor expression and activity. A longstanding …