The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Exercise is known to have beneficial effects on cognition, mood, and the brain. However,
exercise also activates the hypothalamic–pituitary–adrenal axis and increases levels of the …

Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness.
Sex differences in dopaminergic signaling have been acknowledged for decades and have …

The pharmacological modification of dopamine transmission has long been employed as a
therapeutic tool in the treatment of many mental health disorders. However, as many of the …

The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …

Depression and anxiety are more common among females than males and represent a
leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer …

The dopaminergic system can adapt to the different physiological or pathological situations
to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis …

Depression is a major public health concern. Unfortunately, the present antidepressants
often are insufficiently effective, whilst the discovery of more effective antidepressants has …