Biomarker-driven molecular imaging probes in radiotherapy
Background: Biomarker-driven molecular imaging has emerged as an integral part of cancer
precision radiotherapy. The use of molecular imaging probes, including nanoprobes, have …
precision radiotherapy. The use of molecular imaging probes, including nanoprobes, have …
The DNA damage response and inflammation in cancer
Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
A polymeric hydrogel to eliminate programmed death-ligand 1 for enhanced tumor radio-immunotherapy
Programmed death-ligand 1 (PD-L1) is a specialized shield on tumor cells that evades the
immune system. Even inhibited by PD-L1 antibodies, a cycling process constantly transports …
immune system. Even inhibited by PD-L1 antibodies, a cycling process constantly transports …
Supervised discovery of interpretable gene programs from single-cell data
Factor analysis decomposes single-cell gene expression data into a minimal set of gene
programs that correspond to processes executed by cells in a sample. However, matrix …
programs that correspond to processes executed by cells in a sample. However, matrix …
Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy
Z Zheng, J Su, X Bao, H Wang, C Bian, Q Zhao… - Frontiers in …, 2023 - frontiersin.org
Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the
production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to …
production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to …
Radiation-induced tumor immune microenvironments and potential targets for combination therapy
S Guo, Y Yao, Y Tang, Z Xin, D Wu, C Ni… - … and Targeted Therapy, 2023 - nature.com
As one of the four major means of cancer treatment including surgery, radiotherapy (RT),
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …
A Hybrid Nanoadjuvant Simultaneously Depresses PD‐L1/TGF‐β1 and Activates cGAS‐STING Pathway to Overcome Radio‐Immunotherapy Resistance
Currently, certain cancer patients exhibit resistance to radiotherapy due to reduced DNA
damage under hypoxic conditions and acquired immune tolerance triggered by transforming …
damage under hypoxic conditions and acquired immune tolerance triggered by transforming …
Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis
The efficacy of radiotherapy (RT) is limited by inefficient X‐ray absorption and reactive
oxygen species generation, upregulation of immunosuppressive factors, and a reducing …
oxygen species generation, upregulation of immunosuppressive factors, and a reducing …
[HTML][HTML] Radiation-induced PD-L1 expression in tumor and its microenvironment facilitates cancer-immune escape: a narrative review
NH Wang, Z Lei, HN Yang, Z Tang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …
research string comprised various combinations of “radiotherapy”,“programmed death …
The CD47-SIRPα axis is a promising target for cancer immunotherapies
Y Hao, X Zhou, Y Li, B Li, L Cheng - International Immunopharmacology, 2023 - Elsevier
Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …
found on the surface of many cells in the body and uniquely overexpressed by both solid …