Molecular mechanisms of drug resistance
DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
Escape of human solid tumors from T–cell recognition: Molecular mechanisms and functional significance
FM Marincola, EM Jaffee, DJ Hicklin, S Ferrone - Advances in immunology, 1999 - Elsevier
Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
HT Khong, NP Restifo - Nature immunology, 2002 - nature.com
The idea that tumors must “escape” from immune recognition contains the implicit
assumption that tumors can be destroyed by immune responses either spontaneously or as …
assumption that tumors can be destroyed by immune responses either spontaneously or as …
Mesenchymal stem cells avoid allogeneic rejection
Adult bone marrow derived mesenchymal stem cells offer the potential to open a new
frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of …
frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of …
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
M Müller, S Wilder, D Bannasch, D Israeli… - The Journal of …, 1998 - rupress.org
Chemotherapeutic drugs cause DNA damage and kill cancer cells mainly by apoptosis. p53
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …
mediates apoptosis after DNA damage. To explore the pathway of p53-dependent cell …
Does the immune system see tumors as foreign or self?
D Pardoll - Annual review of immunology, 2003 - annualreviews.org
Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it
is clear that tumors express many neoantigens. A central question in cancer immunology is …
is clear that tumors express many neoantigens. A central question in cancer immunology is …
Natural killer cells and cancer
J Wu, LL Lanier - Advances in cancer research, 2003 - books.google.com
Natural killer cells and cancer Page 138 Natural Killer Cells and Cancer Jun Wu1 and Lewis L.
Lanier2 1Shanghai China and Genomics, 2 Department Inc., of and Microbiology Chinese …
Lanier2 1Shanghai China and Genomics, 2 Department Inc., of and Microbiology Chinese …
Neutrophils as immune effector cells in antibody therapy in cancer
LM Behrens, M van Egmond… - Immunological …, 2023 - Wiley Online Library
Tumor‐targeting monoclonal antibodies are available for a number of cancer cell types
(over) expressing the corresponding tumor antigens. Such antibodies can limit tumor …
(over) expressing the corresponding tumor antigens. Such antibodies can limit tumor …
IFN-γ induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression
The mechanism by which IFN-γ inhibits tumor cell growth has not been fully understood.
Here we report that IFN-γ up-regulated the expression of Fas and Fas ligand (FasL) on HT29 …
Here we report that IFN-γ up-regulated the expression of Fas and Fas ligand (FasL) on HT29 …
Mechanistic understanding of curcumin's therapeutic effects in lung cancer
Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …