Progressive neuronal loss is a hallmark of many neurodegenerative diseases, including
Alzheimer's and Parkinson's disease. These pathologies exhibit clear signs of inflammation …

Brain-on-a-chip (BoC) concepts should consider three-dimensional (3D) scaffolds to mimic
the 3D nature of the human brain not accessible by conventional planar cell culturing …

Many brain disorders exhibit altered synapse formation in development or synapse loss with
age. To understand the complexities of human synapse development and degeneration …

Genetic and epigenetic variability between iPSC-derived neural progenitor cells (NPCs)
combined with differences in investigator technique and selection protocols contributes to …

Over 1250 mutations in SCN1A, the Nav1. 1 voltage-gated sodium channel gene, are
associated with seizure disorders including GEFS+. To evaluate how a specific mutation …

Bottom-up neuroscience aims to engineer well-defined networks of neurons to investigate
the functions of the brain. By reducing the complexity of the brain to achievable target …

Nanostructured substrates such as nanowire arrays form a powerful tool for building next-
generation medical devices. So far, human pluripotent stem cell-derived neurons—a …

Patients diagnosed with chromosome microdeletions or duplications, known as copy
number variants (CNVs), present a unique opportunity to investigate the relationship …

Nanostructured cell culture substrates featuring nanowire (NW) arrays have been applied to
a variety of basic cell lines and rodent neurons to investigate cellular behavior or to stimulate …

Neurons derived from human induced pluripotent stem cells (hiPSC-derived neurons) offer
novel opportunities for the development of preclinical models of human neurodegenerative …